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  <xs:element id="espr_BlockedAccountDepositAmountIfSpecifiedNetRevenueDoesNotMeetThreshold" abstract="false" name="BlockedAccountDepositAmountIfSpecifiedNetRevenueDoesNotMeetThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_LiabilityFromSaleOfFutureRevenuesTable" abstract="true" name="LiabilityFromSaleOfFutureRevenuesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="espr_AtTheMarketProgramMember" abstract="true" name="AtTheMarketProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsPremiumPercentage" abstract="false" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsPremiumPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_CashPaymentToBeReceivedUponCertainCommercialMilestones" abstract="false" name="CashPaymentToBeReceivedUponCertainCommercialMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DaiichiSankyoCoLtdMember" abstract="true" name="DaiichiSankyoCoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_RevenueInterestPaymentsRemainingRedemptionValue" abstract="false" name="RevenueInterestPaymentsRemainingRedemptionValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_OneTimePartialCall" abstract="false" name="OneTimePartialCall" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ExclusiveDevelopmentalActivitiesMember" abstract="true" name="ExclusiveDevelopmentalActivitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_NonCashInterestExpenseRelatedToRevenueInterestLiability" abstract="false" name="NonCashInterestExpenseRelatedToRevenueInterestLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RIPAAmendmentToTheSecurityAgreementAndWaiverMember" abstract="true" name="RIPAAmendmentToTheSecurityAgreementAndWaiverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_ConcentrationRiskNumberOfMajorCustomers" abstract="false" name="ConcentrationRiskNumberOfMajorCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_SummaryOfWarrantsAndPreFundedWarrantsOutstandingTableTextBlock" abstract="false" name="SummaryOfWarrantsAndPreFundedWarrantsOutstandingTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="espr_AccruedClinicalDevelopmentCostsCurrent" abstract="false" name="AccruedClinicalDevelopmentCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_NetSalesThresholdAxis" abstract="true" name="NetSalesThresholdAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="espr_ConsecutiveNumberOfMonthsSalesMustBeAtOrAboveMilestoneAmount" abstract="false" name="ConsecutiveNumberOfMonthsSalesMustBeAtOrAboveMilestoneAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" abstract="false" name="DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_RevenueInterestPaymentsRedemptionPercentage" abstract="false" name="RevenueInterestPaymentsRedemptionPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_CollaborativeArrangementAbstract" abstract="true" name="CollaborativeArrangementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_RoyaltyRevenueAndProductSalesBulkTabletsMember" abstract="true" name="RoyaltyRevenueAndProductSalesBulkTabletsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_SpecifiedNetRevenueThresholdTriggeringDepositInBlockedAccount" abstract="false" name="SpecifiedNetRevenueThresholdTriggeringDepositInBlockedAccount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_LiabilityFromSaleOfFutureRevenuesRollForward" abstract="true" name="LiabilityFromSaleOfFutureRevenuesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminates" abstract="false" name="PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminates" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_HypotheticalSalesGeneratedAmount" abstract="false" name="HypotheticalSalesGeneratedAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RevenueInterestLiabilityCurrent" abstract="false" name="RevenueInterestLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RevenueInterestRateInitialRate" abstract="false" name="RevenueInterestRateInitialRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_MinimumAmountOfAnnualNetSalesToQualifyForReducedRevenueInterestRateContingentThreshold" abstract="false" name="MinimumAmountOfAnnualNetSalesToQualifyForReducedRevenueInterestRateContingentThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_CardiovascularRiskMember" abstract="true" name="CardiovascularRiskMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_StockAndWarrantsIssuedDuringPeriodValueNewIssues" abstract="false" name="StockAndWarrantsIssuedDuringPeriodValueNewIssues" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DebtInstrumentExchangeAgreementConvertibleThresholdTradingDays" abstract="false" name="DebtInstrumentExchangeAgreementConvertibleThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_DeferredUpFrontPayment" abstract="false" name="DeferredUpFrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercised" abstract="false" name="ClassOfWarrantOrRightExercised" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_CollaborationRevenueMember" abstract="true" name="CollaborationRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_AmountOfSubsequentInstallmentSubjectToRegulatoryApproval" abstract="false" name="AmountOfSubsequentInstallmentSubjectToRegulatoryApproval" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_OtsukaPharmaceuticalCoLtdMember" abstract="true" name="OtsukaPharmaceuticalCoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_NonCashRightOfUseAsset" abstract="false" name="NonCashRightOfUseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_NetSalesThresholdTwoMember" abstract="true" name="NetSalesThresholdTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_TypeOfRiskDomain" abstract="true" name="TypeOfRiskDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightAdditionalConsiderationOfWarrantsOrRights" abstract="false" name="ClassOfWarrantOrRightAdditionalConsiderationOfWarrantsOrRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="espr_WainwrightMember" abstract="true" name="WainwrightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_PercentageOfIncreaseInRoyaltyRateUponDrawdownOfThirdPayment" abstract="false" name="PercentageOfIncreaseInRoyaltyRateUponDrawdownOfThirdPayment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
</xs:schema>
