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  <xs:element id="espr_HypotheticalSalesGeneratedAmount" abstract="false" name="HypotheticalSalesGeneratedAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_SerometrixMember" abstract="true" name="SerometrixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_AggregateAmountOfPotentialFutureRevenueTotalDevelopmentAndSalesMilestones" abstract="false" name="AggregateAmountOfPotentialFutureRevenueTotalDevelopmentAndSalesMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_NetSalesThresholdDomain" abstract="true" name="NetSalesThresholdDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_RegulatoryPerformanceObligationsMember" abstract="true" name="RegulatoryPerformanceObligationsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_PercentageOfIncreaseInRoyaltyRateUponDrawdownOfThirdPayment" abstract="false" name="PercentageOfIncreaseInRoyaltyRateUponDrawdownOfThirdPayment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_OtsukaPharmaceuticalCoLtdMember" abstract="true" name="OtsukaPharmaceuticalCoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_RevenueInterestRateTierThree" abstract="false" name="RevenueInterestRateTierThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_ProceedsFromAchievementOfMilestoneCompletionOfNustendiMarketingAuthorizationApprovalTransfer" abstract="false" name="ProceedsFromAchievementOfMilestoneCompletionOfNustendiMarketingAuthorizationApprovalTransfer" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PaymentsOnRevenueInterestLiability" abstract="false" name="PaymentsOnRevenueInterestLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_NetSalesThresholdTwoMember" abstract="true" name="NetSalesThresholdTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_ConvertibleSeniorNotesDue2025Member" abstract="true" name="ConvertibleSeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_FuturePaymentMilestoneFirstSubmissionOfJapaneseNewDrugApplicationOtsukaTerritory" abstract="false" name="FuturePaymentMilestoneFirstSubmissionOfJapaneseNewDrugApplicationOtsukaTerritory" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_InducementEquityPlanPlan2017Member" abstract="true" name="InducementEquityPlanPlan2017Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_AccruedClinicalDevelopmentCostsPolicyTextBlock" abstract="false" name="AccruedClinicalDevelopmentCostsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="espr_PercentageOfInvestedCapitalReceivedByDecember312024ToQualifyForSecondReducedRevenueInterestRate" abstract="false" name="PercentageOfInvestedCapitalReceivedByDecember312024ToQualifyForSecondReducedRevenueInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_LiabilityRelatedToRevenueInterestPurchaseAgreementAbstract" abstract="true" name="LiabilityRelatedToRevenueInterestPurchaseAgreementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" abstract="false" name="DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_StockIssuedDuringPeriodValueWarrantsExercised" abstract="false" name="StockIssuedDuringPeriodValueWarrantsExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_NetSalesThresholdOneMember" abstract="true" name="NetSalesThresholdOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_OperatingLeaseIncreaseDecreaseInRightOfUseAssets" abstract="false" name="OperatingLeaseIncreaseDecreaseInRightOfUseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminatesIfPriorToAnniversaryOfClosingDateIfPutOptionIsExercised" abstract="false" name="PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminatesIfPriorToAnniversaryOfClosingDateIfPutOptionIsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_DebtInstrumentAdditionalAmount" abstract="false" name="DebtInstrumentAdditionalAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_CappedCallMember" abstract="true" name="CappedCallMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_HypotheticalRepaymentObligationBasedOnSalesGenerated" abstract="false" name="HypotheticalRepaymentObligationBasedOnSalesGenerated" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminatesPriorToThirdAnniversaryOfClosingDateIfPutOptionIsExercised" abstract="false" name="PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminatesPriorToThirdAnniversaryOfClosingDateIfPutOptionIsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_LicenseForIntellectualPropertyRevenueMember" abstract="true" name="LicenseForIntellectualPropertyRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="espr_RevenueInterestRateInitialRate" abstract="false" name="RevenueInterestRateInitialRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_AmountOfSubsequentInstallmentSubjectToRevenueInterestPurchaseAgreementTermsAndConditions" abstract="false" name="AmountOfSubsequentInstallmentSubjectToRevenueInterestPurchaseAgreementTermsAndConditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_UpFrontPayment" abstract="false" name="UpFrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ShareBasedPaymentArrangementExpenseCapitalizedIntoInventory" abstract="false" name="ShareBasedPaymentArrangementExpenseCapitalizedIntoInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RevenueInterestPurchaseAgreementEffectiveAnnualImputedInterestRate" abstract="false" name="RevenueInterestPurchaseAgreementEffectiveAnnualImputedInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="espr_GrossProceedsFromRevenueInterestPurchaseAgreement" abstract="false" name="GrossProceedsFromRevenueInterestPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_UnamortizedTransactionCostsOnRevenueInterestAgreement" abstract="false" name="UnamortizedTransactionCostsOnRevenueInterestAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_LongTermPurchaseCommitmentInitialTermOfAgreement" abstract="false" name="LongTermPurchaseCommitmentInitialTermOfAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_AccruedClinicalDevelopmentCostsCurrent" abstract="false" name="AccruedClinicalDevelopmentCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionAmount" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_AmountOfSubsequentInstallmentSubjectToAchievementOfSalesThreshold" abstract="false" name="AmountOfSubsequentInstallmentSubjectToAchievementOfSalesThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_TrailingNumberOfMonthsSalesMustBeAtOrAboveMilestoneAmount" abstract="false" name="TrailingNumberOfMonthsSalesMustBeAtOrAboveMilestoneAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
