<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:dd3038be-37a7-4888-962c-80deaffcbbcf,g:017a83a0-29a2-45bb-9d31-8dd18629fd3d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.esperion.com/role/CondensedBalanceSheets" xlink:type="simple" xlink:href="espr-20250331.xsd#CondensedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/CondensedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_0dc44321-4ee5-468a-99db-f4312790fda7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_e648783f-0130-4bdd-ac93-f0e37da549d1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0dc44321-4ee5-468a-99db-f4312790fda7" xlink:to="loc_us-gaap_Liabilities_e648783f-0130-4bdd-ac93-f0e37da549d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_b882a3c8-1990-4783-a8d2-edd25909b466" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0dc44321-4ee5-468a-99db-f4312790fda7" xlink:to="loc_us-gaap_CommitmentsAndContingencies_b882a3c8-1990-4783-a8d2-edd25909b466" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f740c28e-fde3-46d7-ae98-d7b7b95027bc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0dc44321-4ee5-468a-99db-f4312790fda7" xlink:to="loc_us-gaap_StockholdersEquity_f740c28e-fde3-46d7-ae98-d7b7b95027bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_c9da6b6b-a4c6-466e-8a0f-337014d69413" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_c9da6b6b-a4c6-466e-8a0f-337014d69413" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_148da055-69a3-400c-ba40-7ed7e6b90c26" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_148da055-69a3-400c-ba40-7ed7e6b90c26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_AccruedClinicalDevelopmentCostsCurrent_ff6df06f-99bf-4e40-aafc-d41211c50e6f" xlink:href="espr-20250331.xsd#espr_AccruedClinicalDevelopmentCostsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_espr_AccruedClinicalDevelopmentCostsCurrent_ff6df06f-99bf-4e40-aafc-d41211c50e6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableCurrent_94b3a07d-7ffa-4dae-b9d9-4124ab5b9c35" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ConvertibleNotesPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_us-gaap_ConvertibleNotesPayableCurrent_94b3a07d-7ffa-4dae-b9d9-4124ab5b9c35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_b2fd61de-468d-4246-886b-34f95b190b9d" xlink:href="espr-20250331.xsd#espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_b2fd61de-468d-4246-886b-34f95b190b9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_805ef298-a862-4ee8-87ab-93e8dff9d74c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_us-gaap_AccountsPayableCurrent_805ef298-a862-4ee8-87ab-93e8dff9d74c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_RoyaltySaleLiabilityCurrent_efd9affd-6620-4bdb-86f7-bc4017dd4874" xlink:href="espr-20250331.xsd#espr_RoyaltySaleLiabilityCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_espr_RoyaltySaleLiabilityCurrent_efd9affd-6620-4bdb-86f7-bc4017dd4874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_AccruedVariableConsiderationCurrent_d4183f06-4da6-4b66-85c3-401024ab1611" xlink:href="espr-20250331.xsd#espr_AccruedVariableConsiderationCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b0003177-0ae0-4d19-aa9c-0ec901fb9347" xlink:to="loc_espr_AccruedVariableConsiderationCurrent_d4183f06-4da6-4b66-85c3-401024ab1611" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_57627dee-a07f-4e7f-b5a6-1256a6056582" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_0257c8a8-f44e-4a80-b33e-d63a9055e37a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_57627dee-a07f-4e7f-b5a6-1256a6056582" xlink:to="loc_us-gaap_PreferredStockValue_0257c8a8-f44e-4a80-b33e-d63a9055e37a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_c91ca813-c0bc-49d4-9feb-a961ff8de7a0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_57627dee-a07f-4e7f-b5a6-1256a6056582" xlink:to="loc_us-gaap_CommonStockValue_c91ca813-c0bc-49d4-9feb-a961ff8de7a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_44c00c43-58b7-4b46-9067-a636a6ab4aab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_57627dee-a07f-4e7f-b5a6-1256a6056582" xlink:to="loc_us-gaap_AdditionalPaidInCapital_44c00c43-58b7-4b46-9067-a636a6ab4aab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_dfb39245-aee4-4661-a374-da74de872606" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_57627dee-a07f-4e7f-b5a6-1256a6056582" xlink:to="loc_us-gaap_TreasuryStockCommonValue_dfb39245-aee4-4661-a374-da74de872606" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_bab49f30-c2e5-4d74-9049-1a3021b05452" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_57627dee-a07f-4e7f-b5a6-1256a6056582" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_bab49f30-c2e5-4d74-9049-1a3021b05452" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_a24c0d7c-eb4b-4c19-90a8-0cddbcec9abd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_2ad4885a-387b-41da-a64f-5a2df2e16582" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a24c0d7c-eb4b-4c19-90a8-0cddbcec9abd" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_2ad4885a-387b-41da-a64f-5a2df2e16582" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_4fb3fa91-3b21-4be9-8407-3608da5b7cec" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a24c0d7c-eb4b-4c19-90a8-0cddbcec9abd" xlink:to="loc_us-gaap_AssetsCurrent_4fb3fa91-3b21-4be9-8407-3608da5b7cec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_2391ec87-c876-4abd-9f53-9fb999cd941c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a24c0d7c-eb4b-4c19-90a8-0cddbcec9abd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_2391ec87-c876-4abd-9f53-9fb999cd941c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_82b3c92e-2104-4500-9c6c-66a12427d0c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a24c0d7c-eb4b-4c19-90a8-0cddbcec9abd" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_82b3c92e-2104-4500-9c6c-66a12427d0c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_30307dec-8edf-4d4f-b4be-a49016834ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_0333b3e3-a656-4a95-9cc9-4be53e5a7b89" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ConvertibleLongTermNotesPayable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30307dec-8edf-4d4f-b4be-a49016834ee3" xlink:to="loc_us-gaap_ConvertibleLongTermNotesPayable_0333b3e3-a656-4a95-9cc9-4be53e5a7b89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_RoyaltySaleLiabilityNonCurrent_073b1f38-33ab-47a2-868b-742d115d5c98" xlink:href="espr-20250331.xsd#espr_RoyaltySaleLiabilityNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30307dec-8edf-4d4f-b4be-a49016834ee3" xlink:to="loc_espr_RoyaltySaleLiabilityNonCurrent_073b1f38-33ab-47a2-868b-742d115d5c98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_79d1c68f-37da-48d1-9bd3-42bbcb53a44e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30307dec-8edf-4d4f-b4be-a49016834ee3" xlink:to="loc_us-gaap_LiabilitiesCurrent_79d1c68f-37da-48d1-9bd3-42bbcb53a44e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3186dbce-2b0d-47f0-a229-fb4b71759ca2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30307dec-8edf-4d4f-b4be-a49016834ee3" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3186dbce-2b0d-47f0-a229-fb4b71759ca2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebtNoncurrent_79509e1a-a693-46c2-9bd6-75a1fc363101" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLongTermDebtNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30307dec-8edf-4d4f-b4be-a49016834ee3" xlink:to="loc_us-gaap_OtherLongTermDebtNoncurrent_79509e1a-a693-46c2-9bd6-75a1fc363101" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_07f7ad81-71b9-4d57-bd17-398b8b42795c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_07f7ad81-71b9-4d57-bd17-398b8b42795c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c69cb15f-4725-4d90-8413-f4f7f1bbbadf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c69cb15f-4725-4d90-8413-f4f7f1bbbadf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_9ff8fdff-1117-414e-bfdd-cac59ff49c2c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:to="loc_us-gaap_InventoryNet_9ff8fdff-1117-414e-bfdd-cac59ff49c2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_PrepaidInventoryCosts_afb0564e-21ff-4088-87b5-85ca08416f0b" xlink:href="espr-20250331.xsd#espr_PrepaidInventoryCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:to="loc_espr_PrepaidInventoryCosts_afb0564e-21ff-4088-87b5-85ca08416f0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_PrepaidClinicalDevelopmentCostsCurrent_ab5b32ed-6a46-42ae-9cf6-dc146633388b" xlink:href="espr-20250331.xsd#espr_PrepaidClinicalDevelopmentCostsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:to="loc_espr_PrepaidClinicalDevelopmentCostsCurrent_ab5b32ed-6a46-42ae-9cf6-dc146633388b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_6a2b2d6b-4ae5-4e7e-9bb3-eb92f149a0af" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6bc7d84c-5cbb-4c48-a168-ac6fc6278e0b" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_6a2b2d6b-4ae5-4e7e-9bb3-eb92f149a0af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/CondensedStatementsofOperationsandComprehensiveLossIncome" xlink:type="simple" xlink:href="espr-20250331.xsd#CondensedStatementsofOperationsandComprehensiveLossIncome"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/CondensedStatementsofOperationsandComprehensiveLossIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8eb76faf-f4b9-41c4-b6e9-b4f48cfc3a36" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e55be3ca-03ce-4543-adf7-8d301f6e39f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8eb76faf-f4b9-41c4-b6e9-b4f48cfc3a36" xlink:to="loc_us-gaap_OperatingIncomeLoss_e55be3ca-03ce-4543-adf7-8d301f6e39f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_4b08a4f4-5120-4f94-ba53-e917cf44ccab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8eb76faf-f4b9-41c4-b6e9-b4f48cfc3a36" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_4b08a4f4-5120-4f94-ba53-e917cf44ccab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_f17d2c33-c505-441f-8793-e202096cf712" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8eb76faf-f4b9-41c4-b6e9-b4f48cfc3a36" xlink:to="loc_us-gaap_InterestExpenseNonoperating_f17d2c33-c505-441f-8793-e202096cf712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_5f03d182-e6a2-49a2-8edf-11e9ddcdba67" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_e031d8e3-f18a-416d-9d5d-c0811a920335" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_5f03d182-e6a2-49a2-8edf-11e9ddcdba67" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_e031d8e3-f18a-416d-9d5d-c0811a920335" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_ef30faf4-f4ca-4543-8946-a82a6acd38bd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_5f03d182-e6a2-49a2-8edf-11e9ddcdba67" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_ef30faf4-f4ca-4543-8946-a82a6acd38bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_861bdfcb-5f68-4622-b249-18e5676e8597" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_5f03d182-e6a2-49a2-8edf-11e9ddcdba67" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_861bdfcb-5f68-4622-b249-18e5676e8597" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_4159c1cb-88a9-4f33-846f-4252ccbc88d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3e3c0dfd-9b3a-49a4-9fae-1bac47997b6c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_4159c1cb-88a9-4f33-846f-4252ccbc88d9" xlink:to="loc_us-gaap_NetIncomeLoss_3e3c0dfd-9b3a-49a4-9fae-1bac47997b6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b8b960bb-79a6-44df-85b5-912ea93227a3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8c8234fe-c8b8-4faa-80e8-de438a7a1d97" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_b8b960bb-79a6-44df-85b5-912ea93227a3" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8c8234fe-c8b8-4faa-80e8-de438a7a1d97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_a9a316e9-91e3-44d6-a156-65c060645bcc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_b8b960bb-79a6-44df-85b5-912ea93227a3" xlink:to="loc_us-gaap_OperatingExpenses_a9a316e9-91e3-44d6-a156-65c060645bcc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/CondensedStatementsofCashFlows" xlink:type="simple" xlink:href="espr-20250331.xsd#CondensedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/CondensedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d93043b4-5ed8-40b6-89f1-f129eaed3f90" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_04575bdc-9de6-440e-b897-35c24d4bde38" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d93043b4-5ed8-40b6-89f1-f129eaed3f90" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_04575bdc-9de6-440e-b897-35c24d4bde38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_0fa86d77-7940-4466-9a3c-6fe25cf30d75" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d93043b4-5ed8-40b6-89f1-f129eaed3f90" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_0fa86d77-7940-4466-9a3c-6fe25cf30d75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_3748b525-f27e-4969-8aaa-8c92b4fa71dd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d93043b4-5ed8-40b6-89f1-f129eaed3f90" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_3748b525-f27e-4969-8aaa-8c92b4fa71dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_PaymentsFromRevenueInterestPurchaseAgreement_1801d3d3-44b8-4458-ba51-dabd41018dda" xlink:href="espr-20250331.xsd#espr_PaymentsFromRevenueInterestPurchaseAgreement"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d93043b4-5ed8-40b6-89f1-f129eaed3f90" xlink:to="loc_espr_PaymentsFromRevenueInterestPurchaseAgreement_1801d3d3-44b8-4458-ba51-dabd41018dda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_40494580-c5f4-4b5e-b9a4-8e3b56ac7203" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fdb535ae-a004-481d-8003-ea734d8b553e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_40494580-c5f4-4b5e-b9a4-8e3b56ac7203" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fdb535ae-a004-481d-8003-ea734d8b553e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_54e26755-679b-49a4-acc7-7e44ae1b3a80" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0375159c-8475-4cfc-808b-0f336cd54c18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_54e26755-679b-49a4-acc7-7e44ae1b3a80" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0375159c-8475-4cfc-808b-0f336cd54c18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_29d3635c-a514-422a-af89-e2d8bb7f870d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_54e26755-679b-49a4-acc7-7e44ae1b3a80" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_29d3635c-a514-422a-af89-e2d8bb7f870d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6b11c94c-9e1d-4628-ba5b-012ee11f0b74" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_54e26755-679b-49a4-acc7-7e44ae1b3a80" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6b11c94c-9e1d-4628-ba5b-012ee11f0b74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_4b2a2c32-15a3-4a45-8c8a-8fa60cb79d20" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_4b2a2c32-15a3-4a45-8c8a-8fa60cb79d20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_be558510-f7e9-47f6-95e4-91c059e6f1d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_be558510-f7e9-47f6-95e4-91c059e6f1d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_NonCashInterestExpenseRelatedToRoyaltySaleLiability_4e69d32b-6b00-4a3a-8caa-a10c5e16aba7" xlink:href="espr-20250331.xsd#espr_NonCashInterestExpenseRelatedToRoyaltySaleLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_espr_NonCashInterestExpenseRelatedToRoyaltySaleLiability_4e69d32b-6b00-4a3a-8caa-a10c5e16aba7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_555f4b20-34c8-4e8f-b0fc-e45ae48a18f3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_NetIncomeLoss_555f4b20-34c8-4e8f-b0fc-e45ae48a18f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_41228ae7-8532-42eb-b9fb-5771ea7d7f10" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_41228ae7-8532-42eb-b9fb-5771ea7d7f10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_7e54ce35-c511-4044-a5c2-7ca1ebe104d0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_7e54ce35-c511-4044-a5c2-7ca1ebe104d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_NonCashInterestExpenseRelatedToRevenueInterestLiability_818663df-4834-45e4-b9d4-881efe846bc0" xlink:href="espr-20250331.xsd#espr_NonCashInterestExpenseRelatedToRevenueInterestLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_espr_NonCashInterestExpenseRelatedToRevenueInterestLiability_818663df-4834-45e4-b9d4-881efe846bc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_NonCashRoyaltyRevenueRelatedToSaleOfFutureRoyalties_0adbd652-f2c8-4c88-8650-b43db0385a34" xlink:href="espr-20250331.xsd#espr_NonCashRoyaltyRevenueRelatedToSaleOfFutureRoyalties"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_espr_NonCashRoyaltyRevenueRelatedToSaleOfFutureRoyalties_0adbd652-f2c8-4c88-8650-b43db0385a34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_d2f98919-2841-4448-953a-882fba51b02f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_Depreciation_d2f98919-2841-4448-953a-882fba51b02f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_0bbd3912-5ee5-45ec-bd1f-9bc08cd24567" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_ShareBasedCompensation_0bbd3912-5ee5-45ec-bd1f-9bc08cd24567" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_5c4eabec-509e-4c64-9ffc-c401d4a0e9c1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_5c4eabec-509e-4c64-9ffc-c401d4a0e9c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_6d3bece7-c186-4bcb-8bb7-9d4be8c732e7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_6d3bece7-c186-4bcb-8bb7-9d4be8c732e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_9913abee-9b31-4537-9e8c-f6bd7a828ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1d681143-2e36-44d2-9014-08f95cb35a5c" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_9913abee-9b31-4537-9e8c-f6bd7a828ce8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/InventoriesnetDetails" xlink:type="simple" xlink:href="espr-20250331.xsd#InventoriesnetDetails"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/InventoriesnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_b57724cb-510e-437d-8fec-36844222ff09" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_0c48cf6d-6f6e-4821-9b4c-e39e7ceb1a46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b57724cb-510e-437d-8fec-36844222ff09" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_0c48cf6d-6f6e-4821-9b4c-e39e7ceb1a46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_b493cc1c-a4a0-424e-b4ae-07665bed4245" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b57724cb-510e-437d-8fec-36844222ff09" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_b493cc1c-a4a0-424e-b4ae-07665bed4245" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_6a259df9-bfc1-4732-b5c7-6e66c0a5b8ca" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b57724cb-510e-437d-8fec-36844222ff09" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_6a259df9-bfc1-4732-b5c7-6e66c0a5b8ca" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/CashEquivalentsSummaryofCashEquivalentsandShortTermInvestmentsDetails" xlink:type="simple" xlink:href="espr-20250331.xsd#CashEquivalentsSummaryofCashEquivalentsandShortTermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/CashEquivalentsSummaryofCashEquivalentsandShortTermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f02f70ab-d2ff-4ae2-a3dd-a4b245699bc2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_cca67ec3-ca7b-462a-97b9-c583775aed9a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f02f70ab-d2ff-4ae2-a3dd-a4b245699bc2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_cca67ec3-ca7b-462a-97b9-c583775aed9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_2580139f-429b-453d-88c4-b95661295544" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f02f70ab-d2ff-4ae2-a3dd-a4b245699bc2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_2580139f-429b-453d-88c4-b95661295544" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5f4a1d3f-aaf6-41b3-b4a8-8a572dc2af90" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f02f70ab-d2ff-4ae2-a3dd-a4b245699bc2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5f4a1d3f-aaf6-41b3-b4a8-8a572dc2af90" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/DebtScheduleofEstimatedFuturePrincipalPaymentsDetails" xlink:type="simple" xlink:href="espr-20250331.xsd#DebtScheduleofEstimatedFuturePrincipalPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/DebtScheduleofEstimatedFuturePrincipalPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_44e6f4f2-c69c-49ee-925a-3219aca24ec7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_44e6f4f2-c69c-49ee-925a-3219aca24ec7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_e180df32-e1a6-4e74-bbc2-0f27b3814ff6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_e180df32-e1a6-4e74-bbc2-0f27b3814ff6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_b5146a7a-a85b-47a3-8298-01b4a583143c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_b5146a7a-a85b-47a3-8298-01b4a583143c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_b7c01ef1-8e95-44da-baf7-7113c5f8a409" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_b7c01ef1-8e95-44da-baf7-7113c5f8a409" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_921628c4-14b1-4e65-95c5-8aa357ba367c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_921628c4-14b1-4e65-95c5-8aa357ba367c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_2f9a71c5-fcf4-4cec-bec4-d11ca891704b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_ab995ef4-ae88-4e4e-944e-c155490f7576" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_2f9a71c5-fcf4-4cec-bec4-d11ca891704b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/OtherAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="espr-20250331.xsd#OtherAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/OtherAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_3aadf3e6-7624-4796-a90d-d69a21a9a133" xlink:href="espr-20250331.xsd#espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_cbb00c53-d022-478b-924b-603fda2e7a5b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_3aadf3e6-7624-4796-a90d-d69a21a9a133" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_cbb00c53-d022-478b-924b-603fda2e7a5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_65649e1f-6863-4280-97ef-f5a5192f6e55" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_3aadf3e6-7624-4796-a90d-d69a21a9a133" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_65649e1f-6863-4280-97ef-f5a5192f6e55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_caefa82b-35c2-4d33-9029-8785d8647b81" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_3aadf3e6-7624-4796-a90d-d69a21a9a133" xlink:to="loc_us-gaap_InterestPayableCurrent_caefa82b-35c2-4d33-9029-8785d8647b81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_59229e7e-6a78-4d11-90df-883ae84e1024" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_3aadf3e6-7624-4796-a90d-d69a21a9a133" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_59229e7e-6a78-4d11-90df-883ae84e1024" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_espr_AccruedLegalFeesCurrent_c8944786-08a4-4d71-940d-16054f9aef28" xlink:href="espr-20250331.xsd#espr_AccruedLegalFeesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_espr_AccruedLiabilitiesAndEmployeeRelatedLiabilitiesCurrent_3aadf3e6-7624-4796-a90d-d69a21a9a133" xlink:to="loc_espr_AccruedLegalFeesCurrent_c8944786-08a4-4d71-940d-16054f9aef28" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.esperion.com/role/NetLossIncomePerCommonShareCalculationofBasicandDilutedLossIncomePerShareDetails" xlink:type="simple" xlink:href="espr-20250331.xsd#NetLossIncomePerCommonShareCalculationofBasicandDilutedLossIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.esperion.com/role/NetLossIncomePerCommonShareCalculationofBasicandDilutedLossIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7d29b56a-4f1b-4cdc-b19e-a122aa3025c7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_d68929a4-453e-4856-bad9-aa017470932e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7d29b56a-4f1b-4cdc-b19e-a122aa3025c7" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_d68929a4-453e-4856-bad9-aa017470932e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_768e5fce-f99e-421a-ac77-69cd3b7f8569" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7d29b56a-4f1b-4cdc-b19e-a122aa3025c7" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_768e5fce-f99e-421a-ac77-69cd3b7f8569" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_5a4617cb-d41e-4a47-ae48-d81e51afde7a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_61e5cbca-8222-424f-98d6-90a873450ef5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_5a4617cb-d41e-4a47-ae48-d81e51afde7a" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_61e5cbca-8222-424f-98d6-90a873450ef5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestOnConvertibleDebtNetOfTax_aebae7cf-c9ec-407d-9b07-b3c24a6c3f89" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestOnConvertibleDebtNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_5a4617cb-d41e-4a47-ae48-d81e51afde7a" xlink:to="loc_us-gaap_InterestOnConvertibleDebtNetOfTax_aebae7cf-c9ec-407d-9b07-b3c24a6c3f89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1d2819f0-2157-48e4-a0cb-67e1ab9d7425" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_744f8aea-c888-41b6-9200-fde74e412568" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1d2819f0-2157-48e4-a0cb-67e1ab9d7425" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_744f8aea-c888-41b6-9200-fde74e412568" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_afa9c65a-cfde-45b1-b855-2514705853d7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1d2819f0-2157-48e4-a0cb-67e1ab9d7425" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_afa9c65a-cfde-45b1-b855-2514705853d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_e984f452-b94b-4af8-ac05-735384f27e08" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1d2819f0-2157-48e4-a0cb-67e1ab9d7425" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_e984f452-b94b-4af8-ac05-735384f27e08" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
