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  <xs:element id="espr_SaleOfFutureRoyaltiesRollForward" abstract="true" name="SaleOfFutureRoyaltiesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_RoyaltySaleLiabilityDecreaseForRoyaltiesRecognized" abstract="false" name="RoyaltySaleLiabilityDecreaseForRoyaltiesRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_CreditAgreementMember" abstract="true" name="CreditAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_ConvertibleSeniorNotesDue2025Member" abstract="true" name="ConvertibleSeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_ConvertibleSeniorNotesDue2030Member" abstract="true" name="ConvertibleSeniorNotesDue2030Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_ConvertibleSeniorNotesDue2030ExchangeTransactionsMember" abstract="true" name="ConvertibleSeniorNotesDue2030ExchangeTransactionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_ConvertibleSeniorNotesDue2030SubscriptionTransactionsMember" abstract="true" name="ConvertibleSeniorNotesDue2030SubscriptionTransactionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_CappedCallMember" abstract="true" name="CappedCallMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_DebtInstrumentInterestRatePaidInCash" abstract="false" name="DebtInstrumentInterestRatePaidInCash" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentInterestRatePaidInKind" abstract="false" name="DebtInstrumentInterestRatePaidInKind" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentQuarterlyPrincipalRateAfterFourYears" abstract="false" name="DebtInstrumentQuarterlyPrincipalRateAfterFourYears" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentBasisSpreadOnMakeWholePremiumInNextTwoYears" abstract="false" name="DebtInstrumentBasisSpreadOnMakeWholePremiumInNextTwoYears" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentPrepaymentPremiumYearThree" abstract="false" name="DebtInstrumentPrepaymentPremiumYearThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentPrepaymentPremiumYearFour" abstract="false" name="DebtInstrumentPrepaymentPremiumYearFour" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentCovenantMinimumLiquidity" abstract="false" name="DebtInstrumentCovenantMinimumLiquidity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DebtInstrumentOriginalDiscountPremiumPercentage" abstract="false" name="DebtInstrumentOriginalDiscountPremiumPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_NumberOfBusinessDays" abstract="false" name="NumberOfBusinessDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_NumberOfConsecutiveTradingDays" abstract="false" name="NumberOfConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" abstract="false" name="DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentRedemptionOptionPeriodPriorToMaturityDateScheduledTradingDays" abstract="false" name="DebtInstrumentRedemptionOptionPeriodPriorToMaturityDateScheduledTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_DebtInstrumentCovenantRequiredAmountOutstanding" abstract="false" name="DebtInstrumentCovenantRequiredAmountOutstanding" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DebtInstrumentExchangeAgreementConversionWeightedAveragePricePerShareFloor" abstract="false" name="DebtInstrumentExchangeAgreementConversionWeightedAveragePricePerShareFloor" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="espr_DebtInstrumentExchangeAgreementConvertibleThresholdTradingDays" abstract="false" name="DebtInstrumentExchangeAgreementConvertibleThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsPremiumPercentage" abstract="false" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsPremiumPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_A2025NotesAnd2030NotesMember" abstract="true" name="A2025NotesAnd2030NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_AccruedLegalFeesCurrent" abstract="false" name="AccruedLegalFeesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ShareBasedPaymentArrangementOptionPerformanceBasedMember" abstract="true" name="ShareBasedPaymentArrangementOptionPerformanceBasedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_StockOptionAndIncentivePlan2022Member" abstract="true" name="StockOptionAndIncentivePlan2022Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_InducementEquityPlan2017Member" abstract="true" name="InducementEquityPlan2017Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeePercent" abstract="false" name="EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeeAmount" abstract="false" name="EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeeAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanPercentageDiscountOnShares" abstract="false" name="EmployeeStockPurchasePlanPercentageDiscountOnShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanDurationOfOfferingPeriod" abstract="false" name="EmployeeStockPurchasePlanDurationOfOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_CommonStockCapitalSharesReservedForFutureIssuanceIncrease" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceIncrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_AtTheMarketProgramMember" abstract="true" name="AtTheMarketProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_WainwrightMember" abstract="true" name="WainwrightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_WarrantAmendmentAgreementsMember" abstract="true" name="WarrantAmendmentAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_SecuritiesPurchaseAgreementMember" abstract="true" name="SecuritiesPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_CommonStockAndAccompanyingWarrantMember" abstract="true" name="CommonStockAndAccompanyingWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_TheWarrantsMember" abstract="true" name="TheWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_PreFundedWarrantAndAccompanyingWarrantMember" abstract="true" name="PreFundedWarrantAndAccompanyingWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_PreFundedWarrantMember" abstract="true" name="PreFundedWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_WarrantsMember" abstract="true" name="WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_SaleOfStockUnderwriterOptionPeriod" abstract="false" name="SaleOfStockUnderwriterOptionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_SaleOfStockAuthorizedAmount" abstract="false" name="SaleOfStockAuthorizedAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExpired" abstract="false" name="ClassOfWarrantOrRightExpired" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_CommonStockPurchasableUnderPrefundedWarrants" abstract="false" name="CommonStockPurchasableUnderPrefundedWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_CommonStockPurchasableUnderWarrants" abstract="false" name="CommonStockPurchasableUnderWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightPurchasePriceOfWarrantsOrRights" abstract="false" name="ClassOfWarrantOrRightPurchasePriceOfWarrantsOrRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAdditionalConsideration" abstract="false" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAdditionalConsideration" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercised" abstract="false" name="ClassOfWarrantOrRightExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_UnvestedRestrictedStockAndRestrictedStockUnitsMember" abstract="true" name="UnvestedRestrictedStockAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
