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  <xs:element id="espr_ThreeLargestCustomersMember" abstract="true" name="ThreeLargestCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_PropertyAndEquipmentMember" abstract="true" name="PropertyAndEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_SummaryOfSignificantAccountingPoliciesLineItems" abstract="true" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_ConcentrationRiskNumberOfCustomers" abstract="false" name="ConcentrationRiskNumberOfCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_NumberOfSourcesOfRevenue" abstract="false" name="NumberOfSourcesOfRevenue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_DaiichiSankyoEuropeGmbhMember" abstract="true" name="DaiichiSankyoEuropeGmbhMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_OtsukaPharmaceuticalCoLtdMember" abstract="true" name="OtsukaPharmaceuticalCoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_DaiichiSankyoCoLtdMember" abstract="true" name="DaiichiSankyoCoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_NeopharmMember" abstract="true" name="NeopharmMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_ExclusiveDevelopmentalActivitiesMember" abstract="true" name="ExclusiveDevelopmentalActivitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_RoyaltyRevenueFromDSEAndSaleOfBulkTabletsAndMilestonesReceivedMember" abstract="true" name="RoyaltyRevenueFromDSEAndSaleOfBulkTabletsAndMilestonesReceivedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_UpFrontPayment" abstract="false" name="UpFrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_CashPaymentToBeReceivedUponFirstCommercialSales" abstract="false" name="CashPaymentToBeReceivedUponFirstCommercialSales" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PercentageOfRoyaltiesToBeReceivedOnNetSales" abstract="false" name="PercentageOfRoyaltiesToBeReceivedOnNetSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_ContractWithCustomerLiabilityOneTimePaymentCurrent" abstract="false" name="ContractWithCustomerLiabilityOneTimePaymentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RoyaltyRateOnNetSales" abstract="false" name="RoyaltyRateOnNetSales" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_AggregateAmountOfPotentialFutureRevenueTotalDevelopmentAndSalesMilestones" abstract="false" name="AggregateAmountOfPotentialFutureRevenueTotalDevelopmentAndSalesMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ProceedsFromMilestonePayment" abstract="false" name="ProceedsFromMilestonePayment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_FuturePaymentMilestoneSubmissionOfJapaneseNewDrugApplicationOtsukaTerritory" abstract="false" name="FuturePaymentMilestoneSubmissionOfJapaneseNewDrugApplicationOtsukaTerritory" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_FuturePaymentMilestoneFirstNationalHealthInsurancePriceListingOtsukaTerritory" abstract="false" name="FuturePaymentMilestoneFirstNationalHealthInsurancePriceListingOtsukaTerritory" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_FuturePaymentMilestoneAchievementOfDrugTrialOutcomesStudies" abstract="false" name="FuturePaymentMilestoneAchievementOfDrugTrialOutcomesStudies" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_FuturePaymentMilestoneSalesMilestones" abstract="false" name="FuturePaymentMilestoneSalesMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_FutureUpFrontPayment" abstract="false" name="FutureUpFrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_CashPaymentToBeReceivedUponCertainCommercialMilestones" abstract="false" name="CashPaymentToBeReceivedUponCertainCommercialMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_TypeOfRiskAxis" abstract="true" name="TypeOfRiskAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="espr_TypeOfRiskDomain" abstract="true" name="TypeOfRiskDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_CardiovascularRiskOutcomeGreaterThanFifteenButLessThanTwentyPercentMember" abstract="true" name="CardiovascularRiskOutcomeGreaterThanFifteenButLessThanTwentyPercentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_CardiovascularRiskMember" abstract="true" name="CardiovascularRiskMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_PotentialProceedsFromPartnerMilestonePayments" abstract="false" name="PotentialProceedsFromPartnerMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PercentageOfRiskReduction" abstract="false" name="PercentageOfRiskReduction" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_AbbreviatedNewDrugApplicationLitigationNumberOfNoticesReceived" abstract="false" name="AbbreviatedNewDrugApplicationLitigationNumberOfNoticesReceived" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_AccruedLegalFeesCurrent" abstract="false" name="AccruedLegalFeesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_FairValueMeasurementAssetTransfersBetweenLevels" abstract="false" name="FairValueMeasurementAssetTransfersBetweenLevels" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_LiabilityFromSaleOfFutureRevenuesTable" abstract="true" name="LiabilityFromSaleOfFutureRevenuesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="espr_EigerIiiSaLlcMember" abstract="true" name="EigerIiiSaLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_RevenueInterestPurchaseAgreementAmendmentMember" abstract="true" name="RevenueInterestPurchaseAgreementAmendmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_RIPAAmendmentToTheSecurityAgreementAndWaiverMember" abstract="true" name="RIPAAmendmentToTheSecurityAgreementAndWaiverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_LiabilityFromSaleOfFutureRevenuesLineItems" abstract="true" name="LiabilityFromSaleOfFutureRevenuesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_GrossProceedsFromRevenueInterestPurchaseAgreement" abstract="false" name="GrossProceedsFromRevenueInterestPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_AmountOfSubsequentInstallmentSubjectToRevenueInterestPurchaseAgreementTermsAndConditions" abstract="false" name="AmountOfSubsequentInstallmentSubjectToRevenueInterestPurchaseAgreementTermsAndConditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_AmountOfSubsequentInstallmentSubjectToRegulatoryApproval" abstract="false" name="AmountOfSubsequentInstallmentSubjectToRegulatoryApproval" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_AmountOfSubsequentInstallmentSubjectToAchievementOfSalesThreshold" abstract="false" name="AmountOfSubsequentInstallmentSubjectToAchievementOfSalesThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_MilestoneAmountForWorldwideSalesToReceiveThirdPayment" abstract="false" name="MilestoneAmountForWorldwideSalesToReceiveThirdPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ProceedsFromRevenueInterestPurchaseAgreement" abstract="false" name="ProceedsFromRevenueInterestPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RevenueInterestRateTierTwo" abstract="false" name="RevenueInterestRateTierTwo" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_RevenueInterestRateInitialRate" abstract="false" name="RevenueInterestRateInitialRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_PercentageOfInvestedCapitalReceivedByDecember312024ToQualifyForSecondReducedRevenueInterestRate" abstract="false" name="PercentageOfInvestedCapitalReceivedByDecember312024ToQualifyForSecondReducedRevenueInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_RevenueInterestRateTierThree" abstract="false" name="RevenueInterestRateTierThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_PercentageOfIncreaseInRoyaltyRateUponDrawdownOfThirdPayment" abstract="false" name="PercentageOfIncreaseInRoyaltyRateUponDrawdownOfThirdPayment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_MinimumAmountOfAnnualNetSalesToQualifyForReducedRevenueInterestRate" abstract="false" name="MinimumAmountOfAnnualNetSalesToQualifyForReducedRevenueInterestRate" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminates" abstract="false" name="PercentageOfRevenueInterestsPaymentOnWhichAgreementTerminates" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_TrailingNumberOfMonthsSalesMustBeAtOrAboveMilestoneAmount" abstract="false" name="TrailingNumberOfMonthsSalesMustBeAtOrAboveMilestoneAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_MinimumAmountOfAnnualNetSalesToQualifyForReducedRevenueInterestRateContingentThreshold" abstract="false" name="MinimumAmountOfAnnualNetSalesToQualifyForReducedRevenueInterestRateContingentThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_PercentageOfRevenueInterestPaymentsReceivedByDecember312024ToQualifyForThirdPaymentApplicablePercentage" abstract="false" name="PercentageOfRevenueInterestPaymentsReceivedByDecember312024ToQualifyForThirdPaymentApplicablePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_PercentageOfCumulativePurchaserPaymentsGuarantee" abstract="false" name="PercentageOfCumulativePurchaserPaymentsGuarantee" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_SpecifiedNetRevenueThresholdTriggeringDepositInBlockedAccount" abstract="false" name="SpecifiedNetRevenueThresholdTriggeringDepositInBlockedAccount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_BlockedAccountDepositAmountIfSpecifiedNetRevenueDoesNotMeetThreshold" abstract="false" name="BlockedAccountDepositAmountIfSpecifiedNetRevenueDoesNotMeetThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_OneTimePartialCall" abstract="false" name="OneTimePartialCall" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RevenueInterestsPaymentOnWhichAgreementTerminates" abstract="false" name="RevenueInterestsPaymentOnWhichAgreementTerminates" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_LiabilityFromSaleOfFutureRevenuesRollForward" abstract="true" name="LiabilityFromSaleOfFutureRevenuesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_RevenueInterestLiability" abstract="false" name="RevenueInterestLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RevenueInterestLiabilityIncreaseForInterestExpenseRecognized" abstract="false" name="RevenueInterestLiabilityIncreaseForInterestExpenseRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RoyaltySaleLiability" abstract="false" name="RoyaltySaleLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RoyaltySaleLiabilityCapitalizedIssuanceCosts" abstract="false" name="RoyaltySaleLiabilityCapitalizedIssuanceCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_SaleOfFutureRoyaltiesEffectiveAnnualImputedInterestRate" abstract="false" name="SaleOfFutureRoyaltiesEffectiveAnnualImputedInterestRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_SaleOfFutureRoyaltiesRollForward" abstract="true" name="SaleOfFutureRoyaltiesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_RoyaltySaleIssuanceCosts" abstract="false" name="RoyaltySaleIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_RoyaltySaleLiabilityDecreaseForRoyaltiesRecognized" abstract="false" name="RoyaltySaleLiabilityDecreaseForRoyaltiesRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_CappedCallMember" abstract="true" name="CappedCallMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_DebtInstrumentInterestRatePaidInCash" abstract="false" name="DebtInstrumentInterestRatePaidInCash" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentInterestRatePaidInKind" abstract="false" name="DebtInstrumentInterestRatePaidInKind" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentQuarterlyPrincipalRateAfterFourYears" abstract="false" name="DebtInstrumentQuarterlyPrincipalRateAfterFourYears" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentBasisSpreadOnMakeWholePremiumInNextTwoYears" abstract="false" name="DebtInstrumentBasisSpreadOnMakeWholePremiumInNextTwoYears" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentPrepaymentPremiumYearThree" abstract="false" name="DebtInstrumentPrepaymentPremiumYearThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentPrepaymentPremiumYearFour" abstract="false" name="DebtInstrumentPrepaymentPremiumYearFour" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_DebtInstrumentCovenantMinimumLiquidity" abstract="false" name="DebtInstrumentCovenantMinimumLiquidity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DebtInstrumentOriginalDiscountPremiumPercentage" abstract="false" name="DebtInstrumentOriginalDiscountPremiumPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="espr_NumberOfBusinessDays" abstract="false" name="NumberOfBusinessDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_NumberOfConsecutiveTradingDays" abstract="false" name="NumberOfConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" abstract="false" name="DebtInstrumentConvertibleThresholdPercentageOfLastReportedSalePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_DebtInstrumentRedemptionOptionPeriodPriorToMaturityDateScheduledTradingDays" abstract="false" name="DebtInstrumentRedemptionOptionPeriodPriorToMaturityDateScheduledTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="espr_DebtInstrumentCovenantRequiredAmountOutstanding" abstract="false" name="DebtInstrumentCovenantRequiredAmountOutstanding" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DebtInstrumentExchangeAgreementConversionWeightedAveragePricePerShareFloor" abstract="false" name="DebtInstrumentExchangeAgreementConversionWeightedAveragePricePerShareFloor" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="espr_DebtInstrumentExchangeAgreementConvertibleThresholdTradingDays" abstract="false" name="DebtInstrumentExchangeAgreementConvertibleThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsPremiumPercentage" abstract="false" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsPremiumPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_A2025NotesAnd2030NotesMember" abstract="true" name="A2025NotesAnd2030NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_LongTermDebtMaturityYearSix" abstract="false" name="LongTermDebtMaturityYearSix" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_AtTheMarketProgramMember" abstract="true" name="AtTheMarketProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_WainwrightMember" abstract="true" name="WainwrightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_WarrantAmendmentAgreementsMember" abstract="true" name="WarrantAmendmentAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_SecuritiesPurchaseAgreementMember" abstract="true" name="SecuritiesPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_CommonStockAndAccompanyingWarrantMember" abstract="true" name="CommonStockAndAccompanyingWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_TheWarrantsMember" abstract="true" name="TheWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_PreFundedWarrantAndAccompanyingWarrantMember" abstract="true" name="PreFundedWarrantAndAccompanyingWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_PreFundedWarrantMember" abstract="true" name="PreFundedWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_WarrantsMember" abstract="true" name="WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="espr_SaleOfStockAuthorizedAmount" abstract="false" name="SaleOfStockAuthorizedAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExpired" abstract="false" name="ClassOfWarrantOrRightExpired" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_CommonStockPurchasableUnderPrefundedWarrants" abstract="false" name="CommonStockPurchasableUnderPrefundedWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_CommonStockPurchasableUnderWarrants" abstract="false" name="CommonStockPurchasableUnderWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightPurchasePriceOfWarrantsOrRights" abstract="false" name="ClassOfWarrantOrRightPurchasePriceOfWarrantsOrRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAdditionalConsideration" abstract="false" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAdditionalConsideration" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="espr_ClassOfWarrantOrRightExercised" abstract="false" name="ClassOfWarrantOrRightExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_StockOptionAndIncentivePlan2022Member" abstract="true" name="StockOptionAndIncentivePlan2022Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_InducementEquityPlanPlan2017Member" abstract="true" name="InducementEquityPlanPlan2017Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_StockOptionAndIncentivePlan2013Member" abstract="true" name="StockOptionAndIncentivePlan2013Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_IncentiveStockOptionAndRestrictedStockPlan20222017And2013Member" abstract="true" name="IncentiveStockOptionAndRestrictedStockPlan20222017And2013Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_ShareBasedPaymentArrangementOptionPerformanceBasedMember" abstract="true" name="ShareBasedPaymentArrangementOptionPerformanceBasedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_CommonStockCapitalSharesReservedForFutureIssuanceIncrease" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceIncrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeePercent" abstract="false" name="EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeeAmount" abstract="false" name="EmployeeStockPurchasePlanMaximumAnnualContributionsPerEmployeeAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanPercentageDiscountOnShares" abstract="false" name="EmployeeStockPurchasePlanPercentageDiscountOnShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_EmployeeStockPurchasePlanDurationOfOfferingPeriod" abstract="false" name="EmployeeStockPurchasePlanDurationOfOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAsPercentageOfSharesIssuedAndOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAsPercentageOfSharesIssuedAndOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriodForRemainingGrantAmount" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriodForRemainingGrantAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromCessationOfEmploymentWithinWhichOptionsExpireIfNotExercised" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromCessationOfEmploymentWithinWhichOptionsExpireIfNotExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_ShareBasedCompensationArrangementByShareBasedPaymentAwardAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="espr_PrincipalExecutiveOfficeMember" abstract="true" name="PrincipalExecutiveOfficeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_OperatingLeasesITEquipmentLeasesAndAutomobileLeasesMember" abstract="true" name="OperatingLeasesITEquipmentLeasesAndAutomobileLeasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="espr_DeferredTaxAssetsNetOfDeferredTaxLiabilitiesBeforeValuationAllowance" abstract="false" name="DeferredTaxAssetsNetOfDeferredTaxLiabilitiesBeforeValuationAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_OperatingLossCarryforwardsLimitation" abstract="false" name="OperatingLossCarryforwardsLimitation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DeferredTaxAssetRoyaltyPurchaseAgreement" abstract="false" name="DeferredTaxAssetRoyaltyPurchaseAgreement" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_DeferredTaxAssetsTaxDeferredExpenseCapitalizedResearchAndDevelopment" abstract="false" name="DeferredTaxAssetsTaxDeferredExpenseCapitalizedResearchAndDevelopment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="espr_UnvestedRestrictedStockAndRestrictedStockUnitsMember" abstract="true" name="UnvestedRestrictedStockAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
