High low-density lipoprotein cholesterol (LDL-C) has been treatable for decades, but something isn’t working. Atherosclerotic cardiovascular disease continues to increase. Guideline LDL-C targets aren’t met. Patients give up on their medicines entirely. The problem? Patients’ needs are not being met by their cholesterol medicines.

9.6 million patients in the U.S. with high LDL-C are not on statins, often due to tolerability concerns1

Many patients who do everything right – the hard work of changing their diet, exercising and taking their medicine as prescribed – still don’t reach their goals.

Nearly 80% of very high-risk patients did not meet a guideline-recommended LDL-C target2

8.7 million patients in the U.S. don’t reach their LDL-C goals despite taking a statin1

Elevated LDL-C Can Lead to Cardiovascular Disease (CVD), the Number One Cause of Death Globally.3,4 In the U.S., CVD accounts for one in three deaths,1 in Europe, it causes more than half.5 One-third of deaths from CVD occur prematurely in people under 70 years of age.6 And the problem is getting worse: The WHO estimates heart disease deaths will increase 26% by 2030.7

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1. ZS Associates primary and secondary research, Sep-Oct 2018. Primary research N = 350 healthcare practitioners

2. Yan AT, Yan RT, Tan M, et al. Contemporary management of dyslipidemia in high-risk patients: targets still not met. Am J Med. 2006;119(8):676-683. doi:10.1016/j.amjmed.2005.11.015

3.  Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics—2019 update: a report from the American Heart Association. Circulation. 2019;139:00–00. doi:10.1161/CIR.0000000000000659.

4. World Health Organization. Cardiovascular diseases (CVDs) fact sheet.
https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). Accessed October 14, 2020.

5.  World Health Organization. The challenge of cardiovascular disease – quick statistics. https://www.euro.who.int/en/health-topics/noncommunicable-diseases/cardiovascular-diseases/data-and-statistics. Accessed November 30, 2020.

6. World Health Organization. Cardiovascular diseases: https://www.who.int/health-topics/cardiovascular-diseases/#tab=tab_1. Accessed October 14, 2020.

7. Global Status Report on Noncommunicable Diseases 2014. Geneva, Switzerland: World Health Organization; 2014. http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf. Accessed January 11, 2021.